MACOP-B Chemotherapy Regimen

MACOP-B is an acronym that represents a commonly used combination chemotherapy regimen in cancer treatment.

MACOP-B consists of the following drugs:

  • Methotrexate
  • ARA-C (Cytarabine)
  • Cyclophosphamide
  • Oncovin (vincristine)
  • Prednisone
  • Bleomycin

A Typical MACOP-B Regimen

(regimens should be tailored to the individual)

Cycle length: 1 week

Number of cycles: 12

Weeks 1,3,5,7,9,11
Day 1 of every odd-numbered week: Doxorubicin (IV push), cyclophosphamide (IV)
Weeks 2,4,6,8,10,12
Day 1 of weeks 2,6,10: Methotrexate (IV infusion) and leucovorin rescue
Day 1 of every even-numbered week: Vincristine (IV push)
Day 1 of weeks 4,8,12: Bleomycin (IV push)
Days 1-69: Prednisone (oral)
Days 70-84: Prednisone (oral) tapered down
Vomit potential?
Weeks 1,3,5,7,9,11: Moderately high
Weeks 2,6,10: Moderately high
Weeks 4,8,12: None

What it's effective for

The MACOP-B chemotherapy regimen has long been used in the treatment of mediastinal B-cell non-Hodgkin lymphomas, ones that are typically in advanced stages and considered aggressive.

Side effects

Side effects associated with MACOP-B include varying grades of leukopenia, mucositis, infections and anemia. Additionally, since this regimen includes bleomycin, pulmonary toxicity and other lung problems are not uncommon. More on chemotherapy side effects.

Sources

  • Boyiadzis, Michael M. et al. Hematology-Oncology Therapy. 2007. New York: McGraw Hill, Medical Publishing Division.

Significant studies relating to MACOP-B


 

The information provided on CancerTreatment.net is designed to support, not replace, the relationship that exists between a patient/site visitor and his/her health professional. This information is solely for informational purposes and does not constitute the practice of medicine. We encourage all visitors to see a licensed physician or nutritionist if they have any concerns regarding health issues related to diet, personal image and any other topics discussed on this site. Neither the owners or employees of CancerTreatment.net nor the author(s) of site content take responsibility for any possible consequences from any treatment, procedure, exercise, dietary modification, action or application of medication which results from reading this site. Always speak with your primary health care provider before engaging in any form of self treatment. Please see our Legal Statement for further information.